Objective To explore the clinical efficacy of percutaneous minimally invasive spinal internal fixation in the treatment of traumatic thoracolumbar fracture.Methods 80 patients with thoracolumbar fracture treated in Panzhou People's Hospital from August 2022 to August 2023 were selected as the study subjects and were divided into the traditional open pedicle internal fixation group(the control group,n=40 cases)and the percu-taneous minimally invasive spinal internal fixation group(the observation group,n=40 cases)according to different surgical methods.Surgery-related indexes,pain degree,dysfunction,and vertebral function were compared between the two groups.Results Compared with the control group,the patients in the observation group had less intraop-erative blood loss and postoperative drainage(P<0.05),and the surgical incision,operation time,and hospital stay time in the observation group were shorter(P<0.05).There was no significant difference in VAS pain score between the two groups before surgery(P=0.468).One week,three months,and six months after surgery(P<0.05),the VAS pain score of the observation group was significantly lower than that of control group.Before surgery,there were no significant differences in Cobb Angle(t=0.449,P=0.327)and vertebral height ratio(t=0.324,P=0.373)between the two groups.One week after surgery,the Cobb Angle of both groups decreased significantly(P<0.001),and the ratio of injured vertebral body height of both groups increased(P<0.001).Compared with the control group,the Cobb Angle decreased more significantly(P<0.001)and the trauma vertebral height ratio increased more signifi-cantly(P<0.001)in the observation group one week after surgery.Conclusion As a minimally invasive surgical technique for the treatment of traumatic thoracolumbar fractures,percutaneous minimally invasive spinal fixation has obvious advantages in reducing intraoperative blood loss,alleviating postoperative pain,and promoting postop-erative rehabilitation.