Analysis of the Clinical Value of Naloxone Combined with Blood Seeping Treatment in Acute Cerebral Infarction Patients
张凯1
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作者信息
1. 435300 湖北黄冈,蕲春县人民医院神经内科
折叠
摘要
目的 探索纳洛酮联合血塞通在治疗急性脑梗死患者中的可行性.方法 选取2023年1月至2024年1月于蕲春县人民医院就诊的112例急性脑梗死患者为研究对象,随机分为研究组与对照组,每组各56例.研究组给予纳洛酮联合血塞通进行治疗,对照组给予纳洛酮治疗.比较两组患者治疗前后的美国国立卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)评分、肢体运动功能(Fugl-Meyer Assessment,FMA)评分及Barthel指数(Barthel Index,BI)评分,以及临床有效率、血浆脑钠肽(Plasma Brain Natriuretic Peptide,BNP)水平及不良反应.结果 经过两周治疗后,两组患者临床症状体征和自理能力均好转,但研究组患者临床有效率更高(P＜0.05).治疗前,两组患者NIHSS、FMA和BI评分均无显著差异(P＞0.005);治疗后,两组患者NIHSS评分均显著下降(P＜0.001),FMA评分和BI评分均显著升高(P＜0.001),但研究组NIHSS评分下降程度更明显(P＜0.001),FMA评分和BI评分上升程度更明显(P＜0.001).治疗后,两组患者血浆BNP水平均降低,且研究组改善程度优于对照组,差异有统计学意义(P＜0.001).治疗期间,两组患者皮疹、恶心、嗜睡、心动过速等不良反应发生率无显著差异(8.93％vs 12.50％,P＞0.541).结论 纳洛酮联合血塞通治疗急性脑梗死,有利于运动功能和神经功能的恢复,可有效提高患者的生活能力,且不良反应少.
Abstract
Objective To explore the feasibility of naloxone combined with Xuesaitong in the treatment of patients with acute cerebral infarction.Methods 112 patients with acute cerebral infarction who visited our hospital from January 2023 to January 2024 were selected as the research subjects and divided into the study group(n=56)and the control group(n=56).The study group was treated with naloxone combined with Xuesaitong,while the control group was treated with naloxone alone.The NIHSS,FMA,and BI scores,clinical effective rate,plasma BNP levels,and adverse reactions before and after treatment were compared between the two groups.Results After 2 weeks of treatment,the clinical symptoms and self-care abilities of patients in both groups improved,but the study group had a higher clinical effective rate(P＜0.05).Before treatment,there were no significant differences in NIHSS,FMA,and BI scores between the two groups(P＞0.005).After treatment,the NIHSS scores of both groups significantly decreased(P＜0.001),and the FMA and BI scores of both groups significantly increased(P＜0.001),butthe decrease in NIHSS scores and the increase in FMA and BI scores in the study group were more significant than those in the control group(P＜0.001).After treatment,the plasma BNP levels of both groups decreased,and the improvement in the study group was better than that in the control group,with statistical significance(P＜0.001).During the treatment period,there was no significant difference in the occurrence of adverse reactions such as rash,nausea,drowsiness,and tachycardia between the two groups(8.93％vs 12.50％,P＞0.541).Conclusion Nalox-one combined with Xuesaitong in the treatment of patients with acute cerebral infarction can help improve motor and neurological function,effectively enhance life abil-ities,and have few adverse reactions.
关键词
纳洛酮/脑梗死/病理状态/体征和症状
Key words
naloxone/brain infarction/patho-logical conditions,signs and symptoms
维普
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