摘要
目的 探究采用卡托普利舌下含服对高血压急症的救治效果.方法 选取2019年8月至2022年8月就诊于泰康燕园康复医院的200例高血压急症患者为研究对象,分为观察组(卡托普利舌下含服,n=100)和对照组(硝苯地平舌下含服,n=100),对两组患者的临床疗效和不良反应进行比较.结果 8周治疗后,两组患者血压情况和临床症状均好转,且观察组患者临床有效率更高(P＜0.05);治疗前,两组患者收缩压、舒张压和心率均无显著差异;治疗后,两组患者收缩压、舒张压和心率均显著下降(P＜0.05),且观察组收缩压、舒张压和心率下降程度更明显(P＜0.001).两组患者头痛、面部潮红、呼吸急促、心率加快,不良反应发生率无显著差异(P=0.733).结论 卡托普利舌下含服可平稳、有效降低血压,减慢心率,且不良反应少,对高血压急诊的疗效满意.
Abstract
Objective Exploring the therapeutic effect of sublingual administration of captopril on hyper-tensive emergencies.Methods Selecting 200 hypertensive emergency patients who visited Taikang Yanyuan Rehabilitation Hospital from August 2019 to August 2022 as the research subjects,they were divided into the ob-servation group(captopril sublingual administration,n=100)and the control group(nifedipine sublingual admin-istration,n=100).The clinical efficacy and adverse reactions of the two groups were compared.Results After 8 weeks of treatment,the blood pressure and clinical symptoms of both groups were improved,and the clinical effective rate of the observation group was higher than that in the control group(P＜0.05).Before treatment,systolic blood pressure,diastolic blood pressure,and heart rate of the two groupshad no significant difference.After treat-ment,systolic blood pressure,diastolic blood pressure,and heart rate of patients were significantly decreased in both groups(P＜0.05),and the degrees of decline of systolic blood pressure,diastolic blood pressure,and heart rate was more significant in the observation group than those in the control group(P＜0.001).There were no significant difference in the incidence of headache,facial flushing,shortness of breath,and rapid heart rate between the two groups(P=0.733).Conclusion Sublingual administration of captopril can stably and effectively reduce blood pressure,slow down heart rate,and has less adverse reactions,which is satisfactory for emergency treatment of hy-pertension.
维普
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