Study on the Efficacy of Clopidogrel Combined with Dapagliflozin in Treating Elderly Patients with Type 2 Diabetes Mellitus and Acute Cerebral Infarction
Study on the Efficacy of Clopidogrel Combined with Dapagliflozin in Treating Elderly Patients with Type 2 Diabetes Mellitus and Acute Cerebral Infarction
Objective To explore the clinical efficacy of combined therapy of clopidogrel and dapagliflozin in elderly patients with type 2 diabetes mellitus accompanied by acute cerebral infarction(ACI).Methods 104 elderly patients with type 2 diabetes mellitusaccompanied by ACI treated at the Third People's Hospital of Fuji-an University of Traditional Chinese Medicine from October 2020 to October 2023 were included.Patients were randomly assigned into two groups using a random number table:the clopidogrel group(n=52)and the combined therapy group(n=52).The clopidogrel group received standard treatment plus clopidogrel,while the combined ther-apy group received dapagliflozin in addition to standard treatment.Baseline data were compared between the two groups,including fasting blood glucose levels before and after treatment,neurological function deficit scores at the 4th week post-treatment,activities of daily living scores,and mobility function scores.Adverse reactions(includ-ing nausea,vomiting,rash,dizziness)during the treatment period were also monitored.Results At 1,2,3,and 4 weeks post-treatment,fasting blood glucose levels in the combined therapy group were lower than those in the clopidogrel group and tended towards normal levels,with statistically significant differences(P＜0.05).Neurologi-cal function deficit scores(5.00±0.71),activities of daily living scores(70.29±3.52),and mobility function scores(65.38±3.33)in the combined therapy group were su-perior to those in the clopidogrel group(10.90±0.75,58.44±5.30,52.10±5.62),with statistically significant differences(P＜0.05).The overall incidence of adverse reactions was 11.5％(6/52)in the clopidogrel group and 9.6％(5/52)in the combined therapy group,with no statistically significant difference(P＞0.05).Conclusion Combined therapy with clopidogrel and dapagliflozin can effectively control blood glucose levels in elderly patients with type 2 diabetes mellitusaccompanied by ACI,alleviate neurological functional impairment,and improve clini-cal efficacy.
维普
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