摘要
目的 评估血清降钙素原(Procalcitonin,PCT)水平对脓毒症患者病情及预后评估的价值分析.方法 选取2022年3月至2024年4月贵州省黔东南州中医医院收治的52例脓毒症患者作为观察组,选取同期50例健康体检者为对照组.比较脓毒血症患者、健康体检者以及不同程度脓毒血症患者血清PCT水平、APACHE Ⅱ评分和SOFA评分,分析PCT水平、APACHE Ⅱ评分、SOFA评分对脓毒症病情及预后的评估价值.结果 脓毒血症患者PCT水平显著高于健康体检者,差异有统计学意义(P＜0.001).与轻度脓毒症患者比较,中度脓毒症患者PCT水平较高(P＜0.001),APACHE Ⅱ评分和SOFA评分较高(P＜0.001);与中度脓毒症患者比较,重度脓毒症患者PCT水平较高(P＜0.001),重度脓毒症患者APACHE Ⅱ评分和SOFA评分较高(P＜0.001).ROC曲线显示PCT水平对脓毒症患者4周死亡率的预测效能价值更大.结论 PCT水平的检测有利于脓毒症的早期诊断,协助评估病情程度及预后,指导临床治疗.
Abstract
Objective To evaluate the value of serum procalcitonin(PCT)levels in assessing the condition and prognosis of patients with sepsis.Methods 52 sepsis patients admitted to Qiandongnan Traditional Chinese Medicine Hospital in Guizhou Province from March 2022 to April 2024 were selected as the observation group,and 50 healthy individuals who underwent physical examinations during the same period were selected as the control group.We compared the serum PCT levels,APACHE Ⅱ scores,and SOFA scores of sepsis patients,healthy indi-viduals undergoing physical examinations,and patients with different degrees of sepsis,and analyze the evaluation value of PCT levels,APACHE Ⅱ scores,and SOFA scores on the severity and prognosis of sepsis.Results The PCT level in sepsis patients was significantly higher than that in healthy individuals undergoing physical examina-tion,and the difference was statistically significant(P＜0.001).Compared with patients with mild sepsis,patients with moderate sepsis have higher PCT levels(P＜0.001),APACHE Ⅱ scores,and SOFA scores(P＜0.001);Com-pared with patients with moderate sepsis,patients with severe sepsis have higher PCT levels(P＜0.001),and higher APACHE Ⅱ and SOFA scores(P＜0.001).The ROC curve shows that PCT levels have a greater predictive value for the 4-week mortality rate of sepsis patients.Conclusion The detection of PCT levels is beneficial for the early diagnosis of sepsis,assisting in assessing the severity and prognosis of the condition,and guiding clinical treatment.
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