Objective To analyze the diagnostic value of coronary computed tomography angiography(CTA)in coronary artery disease(CAD).Methods This study selected 104 suspected CAD patients who visited Li-ping County People's Hospital from May 2021 to October 2023.All patients underwent both coronary angiography(CAG)and CTA.The diagnostic performance of CTA,as well as the detection rate of lesion location and severity,were evaluated.Results Digital subtraction angiography(DSA)showed 94 positive and 10 negative cases;CTA showed 92 positive and 12 negative cases.Using CAG as the gold standard for CAD diagnosis,the sensitivity of CTA was 96.81%(91/94),specificity was 90.00%(9/10),and accuracy was 96.15%.CAG detected 201 positive coronary arteries,while CTA detected 196 positive coronary arteries,with a total detection rate of 97.51%.The de-tection accuracy of CTA for the left main coronary artery,left anterior descending artery,left circumflex artery,and right coronary artery was 98.19%,97.50%,97.73%,and 96.77%,respectively.There was no significant differ-ence in detection rates between CTA and CAG for lesions in these arteries(Fisher's exact test,all P>0.05).The de-tection accuracy of CTA for mild stenosis,moderate stenosis,severe stenosis,and occlusion was 95.92%,96.55%,98.25%,and 100.00%,respectively.For these stenosis categories,there was no significant difference in detection rates between CTA and CAG(all Pvalue>0.05).Conclusion CTA has high sensitivity,specificity,and accuracy in the diagnosis of CAD.It can accurately locate the distribution of coronary artery lesions and precisely assess the degree of stenosis.CTA and CAG have similar diagnostic performance.