Efficacy of Tirofiban Hydrochloride Injection in the Treatment of Acute Cerebral Infarction Beyond the Intravenous Thrombolysis Time Window:An Observational Study
Efficacy of Tirofiban Hydrochloride Injection in the Treatment of Acute Cerebral Infarction Beyond the Intravenous Thrombolysis Time Window:An Observational Study
Objective To explore the efficacy of tirofiban treatment in patients with acute cerebral infarction beyond the transvenous thrombolysis window.Method 102 patients with acute cerebral infarction beyond the transvenous thrombolysis window admitted to Renhuai People's Hospital from June 2021 to June 2023 were select-ed.They were divided into the observation group(intravenous infusion of tirofiban hydrochloride and sodium chlo-ride injection)and the control group(oral aspirin enteric coated tablets+clopidogrel bisulfate tablets).We compared the clinical efficacy,neurological function,oxidative stress,inflammation levels,and adverse reactions between the two groups.Results The treatment efficacy rate of the observation group(92.16％)was higher than that of the control group(0.59％),and the difference was statistically significant(P=0.005).After 7 days and 2 weeks of treatment,both groups showed improvement in neurological function,and the NIHSS scores in the observation group were lower than those in the control group(P values＜0.001).After treatment,the levels of malondialdehyde(Mad)decreased in both groups,while the levels of glutathione peroxidase(GPx)and superoxide dismutase(SOD)increased;The Mad of the observation group was lower than that of the control group(P＜0.001),while the GPx and SOD of the observation group were higher than those of the control group(both P values＜0.001);Both groups showed a decrease in high-sensitivity C-reactive protein(hs CRP),interleukin-6(IL-6),and tumor necrosis fac-tor-α(TNF-α).The inflammatory indicators in the observation group were lower than those in the control group(P＜0.001).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P＞0.05).Conclusion Tirofiban can effectively improve the neurological function,reduce oxidative stress and inflammatory response in patients with acute cerebral infarction beyond the time window of intravenous thrombolysis,with high safety and signifi-cant clinical efficacy.
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