Objective To investigate the effects of propofol in anesthesia for patients undergoing modified electroconvulsive therapy(ECT).Methods A total of 200 patients who received modified ECT at Pufang Hospi-tal in Chibi from December 2022 to December 2023 were included in the study.Based on the choice of anesthetic,patients were divided into two groups:the observation group(n=100,anesthetized with propofol)and the control group(n=100,anesthetized with thiopental sodium).The anesthetic effects,vital signs,and incidence of adverse re-actions were compared between the two groups.Results The time required to restore spontaneous breathing and to regain consciousness in the observation group was significantly shorter than in the control group(P<0.001).Be-fore anesthesia,there were no significant differences between the two groups in heart rate(HR),oxygen saturation(SpO2),and systolic blood pressure(SBP)levels(P>0.05).After anesthesia,HR did not significantly change from pre-anesthesia levels in either group(P>0.05),while SpO2 and SBP levels decreased compared to pre-anesthesia levels(P<0.05).Post-anesthesia,there were no significant differences between the two groups in HR,SpO2,and SBP levels(P>0.05).In the observation group,7 patients experienced adverse reactions(7.00%),significantly low-er than the 24 patients in the control group who experienced adverse reactions(24.00%),P<0.001.Conclusion Propofol effectively reduces the duration of anesthesia in patients undergoing modified ECT,has minimal impact on HR,blood pressure,and SpO2,and is associated with a low incidence of adverse reactions,thereby ensuring both the efficacy and safety of anesthesia.