Objective To compare the clinical effects of different intracranial pressure reduction methods in the emergency treatment of patients with severe traumatic brain injury(TBI)combined with shock.Methods A retrospective study was conducted on patients admitted to Anhai Hospital of Jinjiang City from January 2021 to De-cember 2023.According to the emergency treatment methods,100 patients with severe TBI and shock were divided into the observation group(hypertonic saline)and the control group(mannitol).Brain injury-related indicators,inflammatory factors,and rescue efficiency were compared between the two groups.Results Before treatment,there were no significant differences between the two groups in intracranial pressure(ICP),cerebral oxygen uptake rate,and S100B protein(P＞0.05).After treatment,ICP,cerebral oxygen uptake rate,and S100B protein levels in both groups decreased significantly(P＜0.05),with the observation group showing lower levels than those of the control group(P＜0.05).Before treatment,there were no significant differences in IL-6,CRP,and TNF-α levels be-tween the two groups(P＞0.05).After treatment,IL-6,CRP,and TNF-α levels in both groups decreased significant-ly(P＜0.05),with the observation group having lower levels than those of the control group(P＜0.05).The rescue success rate in the observation group was significantly higher than that in the control group(P＜0.05).Conclusion:The use of hypertonic saline in the emergency treatment of severe TBI combined with shock can effectively im-prove brain injury,reduce the release of inflammatory factors,and lower the mortality rate of patients.
维普
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