Drug-induced liver injury(DILI)refers to liver damage caused by a drug or its metabolites.In Chi-na,it is often attributed to traditional Chinese herbal medicines,dietary supplements,cosmetic and slimming drugs,and anti-tuberculosis medications.DILI is also a significant clinical cause of acute liver failure.This paper provides a comprehensive review of the mechanisms and biomarkers of DILI,aiming to enhance the safety of clinical drug use.