Objective To analyze the anesthetic effect of dexmedetomidine combined with remifentanyl in patients with acute hypertensive intracerebral hemorrhage.Methods A total of 92 patients who came to Guang-dong Sanjiu Brain Hospital for treatment of acute hypertensive intracerebral hemorrhage from February 2022 to February 2024 were enrolled,and they were divided into observation group(dexmedetomidine+remifentanil,n=46)and control group(propofol+remifentanil,n=46).Blood gas indexes and sedation degree were compared at different time points.S100β level,perioperative adverse reactions.Results There was no significant difference in blood gas analysis of PaCO2,PaO2 and pH levels between the two groups at different time points(P＞0.05).There was no significant difference in the Ramsay score of sedation between the two groups at T1(P=0.187),and the Ramsay score of the observation group in T2～T5 was significantly higher than that in the control group at other time points(P＜0.05).The central nervous system-specific protein S100β in the observation group was significantly higher than that in the control group at 6 h,12 h and 24 h at different time points(P＜0.001).In the perioperative period,the to-tal incidence of adverse reactions to anesthesia in the observation group was 10.87％(5/46),which was significantly lower than that in the control group 23.91％[(13/46),P=0.036].Conclusions In patients with acute hyperten-sive intracerebral hemorrhage,dexmedetomidine anesthesia does not affect the blood gas indexes,and the sedative and analgesic effect is significant,which is conducive to the protection of brain tissue,and there are few periopera-tive adverse reactions.
维普
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