Objective To analyze the diagnostic and therapeutic efficacy of hysteroscopy in patients with acute uterine bleeding. Methods A retrospective analysis was conducted on the clinical data of 100 patients with acute uterine bleeding treated in the emergency department of Dingxi People's Hospital from April 2023 to April 2024. Patients were divided into an observation group (hysteroscopy,n=50) and a control group (ultrasound combined with diagnostic curettage,n=50) based on the diagnostic and therapeutic methods used. Pathological examination results were used as the standard to evaluate the diagnostic and therapeutic outcomes of hysteroscopy and the combined approach of ultrasound and diagnostic curettage. Results In the observation group,47 patients had diagnostic results consistent with pathology,with a lesion detection rate of 94.00%,whereas in the control group,29 patients had diagnostic results consistent with pathology,with a lesion detection rate of 58.00% . The lesion detection rate was significantly higher in the observation group compared to the control group (P<0.001). Before treatment,there were no significant differences in hemoglobin levels and endometrial thickness between the two groups (P>0.05). After treatment,hemoglobin levels increased in both groups (P<0.001),with the observation group showing significantly higher post-treatment hemoglobin levels compared to the control group (P<0.001). Both groups showed improvement in endometrial thickness post-treatment (P<0.001),with the observation group displaying significantly lower endometrial thickness than the control group (P<0.001). The overall clinical efficacy rate was 100.00% in the observation group and 84.00% in the control group,with the observation group showing a significantly higher overall clinical efficacy rate (P<0.05). Complications occurred in 2 patients in the observation group,with a total complication rate of 4.00%,while 11 patients in the control group experienced complications,with a total complication rate of 22.00% . The total complication rate was significantly lower in the observation group compared to the control group (P<0.05). Conclusion Hysteroscopy is a safe and effective method for ac-curately diagnosing and treating acute uterine bleeding.