摘要
目的 探讨血液净化治疗对急性肾损伤(AKI)患者治疗效果和炎症因子水平影响情况.方法 回顾性选取2021年4月至2023年4月在钦州市第二人民医院进行治疗的急性肾损伤患者85例,采取随机数字表法分为对照组(42例)、观察组(43例).对照组患者予以常规方法治疗,观察组患者予以连续性血液净化.比较治疗后肾功能、炎症因子、血流动力学及SOFA和APACHEII评分情况.结果 观察组经治疗后,Scr水平、BUN水平和Cys-C水平相较于对照组均下降(P<0.05);PCT水平、TNF-α水平和IL-6水平相较于对照组均有所降低(P<0.05);观察组经治疗后,观察组的PaO2水平、CVP水平、HR水平较于对照组均下降(P<0.05);治疗后,观察组的SOFA、APACHEII评分较于对照组均下降(P<0.05).结论 急性肾损伤血液净化治疗可明显改善患者肾功能,降低炎症因子的水平,改善血流动力学指标情况,降低SOFA、APACHEII评分,利于机体功能的恢复,值得在临床治疗中借鉴推广.
Abstract
Objective To investigate the effects of blood purification therapy on the treatment outcomes and inflammatory marker levels in patients with acute kidney injury (AKI). Methods A total of 85 patients with acute kidney injury,treated at the Second People's Hospital of Qinzhou from April 2021 to April 2023,were selected and randomly assigned into two groups using a random number table:the control group (42 patients) and the observation group (43 patients). The control group received conventional treatment,while the observation group was treated with continuous blood purification. Kidney function,inflammatory markers,hemodynamic parameters,and SOFA and APACHE Ⅱ scores were compared between the two groups after treatment. Results After treatment,the observa-tion group showed significantly greater reductions in serum creatinine (Scr),blood urea nitrogen (BUN),and cystatin C (Cys-C) levels compared to the control group (P<0.05). Inflammatory markers,including procalcitonin (PCT),tu-mor necrosis factor-alpha (TNF-α),and interleukin-6 (IL-6),were also significantly lower in the observation group (P<0.05). Additionally,the observation group had a significant decrease in PaO2,central venous pressure (CVP),and heart rate (HR) compared to the control group (P<0.05). After treatment,SOFA and APACHE Ⅱ scores in the obser-vation group were significantly lower than those in the control group (P<0.05). Conclusion Blood purification therapy in patients with acute kidney injury can significantly improve kidney function,reduce inflammatory marker levels,enhance hemodynamic stability,and lower SOFA and APACHE Ⅱ scores,which are beneficial for the recovery of organ function. This treatment approach is worthy of clinical application and further promotion.
维普
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