摘要
目的 分析对于细菌性阴道炎(Bacterial Vaginosis,BV),采取苯扎氯铵溶液联合盐酸环丙沙星栓治疗方案的临床疗效及复发率的影响.方法 回顾性分析2021年9月至2023年10月在惠安县妇幼保健院就诊的50例BV患者为研究对象;根据治疗药物的不同分为苯扎氯铵溶液联合盐酸环丙沙星栓治疗组(观察组,n=25)和常规盐酸环丙沙星栓治疗组(对照组,n=25).分析两组研究对象临床疗效、临床症状缓解时间、复发情况、炎症因子水平及氧化应激指标.结果 观察组研究对象中24例(96.00％)有效,明显高于对照组研究对象的19例(76.00％),差异有统计学意义(P<0.05).观察组研究对象外阴瘙痒缓解时间、白带异常缓解时间、外阴疼痛缓解时间、黏膜充血缓解时间均明显比对照组短(P<0.05).观察组患者复发率为4.00％,明显低于对照组的28.00％(P<0.05).治疗前,两组研究对象IL-2、IL-8、IL-13、NO、SOD、ET-1、MDA水平均无显著差异(P>0.05);治疗后,观察组IL-2、IL-8、IL-13、ET-1、MDA水平均明显低于对照组(P<0.001),NO、SOD水平明显高于对照组(P<0.001).结论 对于BV患者采取苯扎氯铵溶液联合盐酸环丙沙星栓的治疗方案临床疗效显著,显著缩短临床症状缓解时间,降低治疗后的复发率,明显改善炎症因子水平和氧化应激指标,有利于患者病情的恢复.
Abstract
Objective To analyze the clinical efficacy and impact on recurrence rate of benzalkonium chloride solution combined with ciprofloxacin hydrochloride suppositories in the treatment of bacterial vaginosis (BV). Methods A retrospective analysis was conducted on 50 BV patients treated at the Hui'an County Maternal and Child Health Hospital from September 2021 to October 2023. Patients were divided into two groups based on the treatment regimen:the observation group (n=25),treated with benzalkonium chloride solution combined with ciprofloxacin hydrochloride suppositories,and the control group (n=25),treated with ciprofloxacin hydrochloride suppositories alone. The clinical efficacy,symptom relief time,recurrence rate,levels of inflammatory factors,and oxidative stress indicators were analyzed between the two groups. Results In the observation group,24 patients achieved effective outcomes,with a clinical efficacy rate of 96.00％,significantly higher than the control group's 76.00％ (P<0.05). The observation group also exhibited shorter times for relief of vulvar pruritus (P<0.001),abnor-mal vaginal discharge (P<0.05),vulvar pain (P<0.05),and mucosal congestion (P<0.05),all statistically significant compared to the control group. The recurrence rate in the observation group was 4.00％,significantly lower than 28.00％ in the control group (P<0.05). Before treatment,there were no significant differences in IL-2,IL-8,IL-13,NO,SOD,ET-1,and MDA levels between the two groups (P>0.05). After treatment,the observation group showed significantly lower levels of IL-2 (P<0.001),IL-8 (P<0.001),IL-13 (P<0.001),ET-1 (P=0.007),and MDA (P<0.001),and significantly higher lev-els of NO (P=0.002) and SOD (P=0.001) compared to the control group,all with statistical significance. Con-clusion The treatment regimen of benzalkonium chloride solution combined with ciprofloxacin hydrochloride suppositories demonstrates significant clinical efficacy for BV patients. It notably shortens symptom relief time,reduces post-treatment recurrence rates,improves levels of inflammatory factors and oxidative stress markers,and promotes patient recovery.
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