Objective To analyze the clinical characteristics of acute poisoning in children of different age groups in this region,in order to provide a basis for formulating scientific and effective prevention and treatment measures. Methods Clinical data from 333 cases of acute poisoning in children admitted to the Pediatric Emergen-cy Department of the Second Affiliated Hospital of Zunyi Medical University between March 2019 and February 2024 were retrospectively analyzed to determine the types and characteristics of poisoning. Results Acute poisoning in children occurs throughout the year,with a higher incidence in spring and summer (60.6%). Boys account for 55% of the cases,while girls account for 45%. The median age is 3.05 years,with higher incidence rates observed in toddlers (38.7%) and preschool-aged children (27%). The most common type of poisoning involves commonly used medica-tions,primarily through oral ingestion. There are statistically significant differences in poisoning cases across gender,age,and season (P<0.05). A total of 289 children (86.79%) sought medical care within 6 hours,with a median time to presentation of 1.34 hours (range 0.57~3.82 hours). All cases were successfully treated,with no fatalities. Conclu-sion The peak incidence of acute poisoning in children occurs in toddlers and preschool-aged groups,with a higher prevalence in boys compared to girls. In adolescence,self-administration is the predominant form of poisoning. To prevent acute poisoning in children,it is essential to enhance public awareness,improve caregivers' vigilance regard-ing safety,and focus on the storage and use of potentially toxic substances. Additionally,fostering good dietary and hygiene habits in children and addressing the mental health of adolescents are crucial preventive measures.