摘要
目的 分析胃癌患者血清糖类抗原724(Carbohydrate Antigen 724,CA724)、癌胚抗原(Carcinoembryonic Antigen,CEA)及糖类抗原199(Carbohydrate Antigen 199,CA199)的表达水平及临床意义.方法 回顾性分析晋江市医院(上海市第六人民医院福建医院)检验科在2022年1月至12月收治的72例胃癌患者的临床资料,所有患者经国际抗癌联盟公布的TNM(Tumor Node Metastasis Classification,TNM)分类法分为Ⅰ期11例、Ⅱ期36例、Ⅲ期20例、Ⅳ期5例.统计比较不同胃癌分期患者的血清CA724、CEA、CA199表达水平,并分析血清CA724、CEA、CA199高表达患者的临床特征.结果 Ⅱ期患者的血清CA724、CEA、CA199表达水平高于Ⅰ期,Ⅲ期患者的血清CA724、CEA、CA199表达水平高于Ⅱ期,Ⅳ期患者的血清CA724、CEA、CA199表达水平高于Ⅲ期,差异均有统计学意义(P<0.05).血清CA724、CEA、CA199高表达患者性别、年龄范围占比无统计学差异(P>0.05),但血清CA724、CEA、CA199高表达患者肿瘤直径≥5cm、弥漫型、高/中分化、有淋巴结转移、生存期<30个月等占比均高于肿瘤直径<5cm、肠型、低分化、无淋巴结转移、生存期>30个月(P<0.05).结论 胃癌患者血清CA724、CEA、CA199表达水平与肿瘤分级密切相关,能反映其临床特征,可作为评估患者预后的检测指标.
Abstract
Objective To analyze the expression levels and clinical significance of serum carbohydrate anti-gen 724 (CA724),carcinoembryonic antigen (CEA),and carbohydrate antigen 199 (CA199) in patients with gastric cancer. Methods A retrospective analysis was conducted on the clinical data of 72 gastric cancer patients treated at Jinjiang City Hospital (Fujian Hospital of Shanghai Sixth People's Hospital) from January to December 2022. Patients were classified according to the TNM staging system published by the Union for International Cancer Con-trol:11 cases in stage Ⅰ,36 cases in stage Ⅱ,20 cases in stage Ⅲ,and 5 cases in stage IV. The expression levels of serum CA724,CEA,and CA199 were compared across different stages of gastric cancer,and the clinical character-istics of patients with high serum CA724,CEA,and CA199 expression were analyzed. Results The expression levels of serum CA724,CEA,and CA199 were higher in stage Ⅱ patients than in stage I,higher in stage Ⅲ patients than in stage Ⅱ,and higher in stage Ⅳ patients than in stage Ⅲ,with statistically significant differences (P<0.05). No statistically significant differences in the gender and age distribution of patients with high serum CA724,CEA,and CA199 expression (P>0.05). However,patients with high serum CA724,CEA,and CA199 expression had a higher proportion of tumor diameter ≥ 5 cm,diffuse type,high/moderate differentiation,lymph node metastasis,and survival period<30 months compared to those with tumor diameter<5 cm,intestinal type,low differentiation,no lymph node metastasis,and survival period>30 months (P<0.05). Conclusion The expression levels of se-rum CA724,CEA,and CA199 in gastric cancer patients are closely related to tumor staging and can reflect clinical characteristics,suggesting their potential as biomarkers for evaluating patient prognosis.
维普
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