Objective To analyze the clinical value of open reduction and percutaneous Kirschner wire fixa-tion in pediatric patients with irreducible distal radius fractures. Methods A retrospective analysis was conducted on the clinical data of 60 pediatric patients with irreducible distal radius fractures treated at Affiliated Mindong Hospi-tal of Fujian Medical University from May 2019 to May 2023. Based on the surgical approach,patients were divided into an observation group (open reduction with percutaneous Kirschner wire fixation,n=30) and a control group (open reduction with plate fixation,n=30). Perioperative indicators,healing time,wrist pain and range of motion,clinical efficacy,and complication rates were compared between the two groups. Results The observation group showed significantly shorter operative time,intraoperative blood loss,hospitalization time,fracture healing time,and fixation removal time compared to the control group (P<0.001). Postoperatively,both groups exhibited significant reductions in Garland-Weley and PRWE scores compared to preoperative levels (P<0.001). Additionally,the postoperative Gar-land-Weley and PRWE scores were significantly lower in the observation group than in the control group (P<0.001). The excellent and good clinical efficacy rates did not differ significantly between the two groups (P>0.05). However,the complication rate in the observation group was significantly lower than that in the control group (P<0.05). Con-clusion For pediatric patients with irreducible distal radius fractures,open reduction with percutaneous Kirschner wire fixation offers minimal trauma,supports fracture healing,promotes wrist function recovery,and demonstrates significant clinical efficacy with a lower incidence of ad-verse reactions.