Objective To explore the clinical value of using clindamycin hydrochloride in the treatment of acute pelvic inflammatory disease in primary hospitals. Methods 120 patients with acute pelvic inflammatory disease who visited the Community Health Service Center in Kenli District,Dongying City from January 2021 to December 2023 were randomly included. They were divided into an observation group and a control group using a random number table method,with 60 patients in each group. The control group patients were given ceftriaxone and metronidazole;Observation group patients were given ceftriaxone+metronidazole+clindamycin hydrochloride,and the clinical symptom improvement time,inflammatory factor levels,clinical efficacy,and safety were compared be-tween the two groups of patients. Results The observation group had a shorter time for the recovery of vaginal discharge and menstruation,as well as the disappearance of uterine tenderness,lumbosacral pain,and lower abdom-inal bloating compared to the control group (P<0.001). Before treatment,there was no significant difference in in-flammatory markers such as C-reactive protein (CRP),transforming growth factor-β (TGF-β),and interleukin-18 (IL-18) between the two groups of patients (P>0.05);After treatment,all inflammatory indicators improved (P<0.001),and the levels of CRP and IL-18 in the ob-servation group were lower than those in the control group (P<0.001),while the level of TGF-β was higher than that in the control group (P<0.001). The total clin-ical effective rate of the observation group was 95.00％ (57/60),which was higher than the control group's 76.67％ (46/60) (P<0.05). The total incidence of adverse reactions in the observation group was 5.00％ (3/60),which was not significantly different from the 11.67％ (7/60) in the control group (P>0.05). Conclusion Clindamycin hy-drochloride can effectively improve the clinical symptoms and signs of acute pelvic inflammatory disease,control the progression of inflammation,and have fewer adverse reactions. The combination therapy with ceftriaxone and metronidazole is effective in treating acute pelvic inflammatory disease.
维普
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