Clinical study on the combination of intravenous anticoagulation with agatroban and ateplase in the treatment of acute severe intracranial arterial stenosis ischemic stroke
Objective To explore the clinical effect of intravenous anticoagulation with Agatroban combined with Ateplase in the treatment of severe acute intracranial arterial stenosis ischemic stroke.Methods A total of 166 patients with severe acute intracranial artery stenosis and is-chemic stroke who were treated in the hospital from January 2022 to February 2023 were selected in this study.They were randomly(Random odd and even number method)divided into a control group and an observation group,with 83 patients in each group.The patients in the control group received routine treatments such as dehydration,lipid-lowering therapy,and alteplase,while in the observation group received a combination of control group and intravenous anticoagulant therapy with agatroban.After 4 weeks of treatment,the clinical efficacy of the two groups were compared.the National Institutes of Health Stroke Scale(NIHSS)scores,Modified Rankin Scale(mRs)scores,and Simplified Fugl Meyer Limb Motor Function Scale(FMA)scores before and after 2 and 4 weeks of treatment were compared.The adverse reactions during treatment between two groups were compared.Results Compared with the control group,the total effective rate of the observation group was significantly higher(P<0.05).After 2 and 4 weeks of treatment,compared to the control group,the observation group had significantly lower NIHSS and mRs scores(P<0.05).After 2 and 4 weeks of treat-ment,compared to the control group,the observation group had significantly higher FMA scores(P<0.05).During the intervention process,no adverse reactions such as skin bleeding,cerebral hemorrhage,nausea and vomiting,or gingival bleeding were observed in both groups.Conclusion The clinical effect of intravenous anticoagulation combined with ateplase in the treatment of severe acute intracranial arterial stenosis ischemic stroke is significant,which can significantly improve the patient's neurological and motor functions,and has high safety,and it is worth promoting and applying.
Ischemic strokeSevere stenosis of intracranial arteriesAteplaseAgaqubanClinical effects
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