Objective To discuss the expression characteristics and predictive value of PD-L1 and CD8+ T lymphocytes in Luminal type breast cancer.Methods A total of 54 cases of Luminal type breast cancer treated in our hospital from January 2022 to October 2023 were collected.Clinical data(age,family history,comorbidities,etc.),pathologic data(TNM stage,PR%,pathologic grading,etc.)were collected,and independent factors of survival were determined using Cox survival analysis.Results CD8+ T expression in Luminal type breast cancer patients was statistically different in terms of menopausal status,tumor stage,Ki-67,and programmed death ligand 1(PD-L1)in tumor cells expression in tumor cells correlated with TNM stage,TIL score,PR%,Ki-67,molecular typing,PD-L1 expression in tumor infiltrating lymphocytes(TILs)TNM stage,TIL score,PR%,Ki-67,molecular typing,ER%,and CD8+ T expression correlated with tumor cells,PD-L1 expression in TILs was statistically different,and independent risk factors for survival in patients with Luminal type breast cancer included PR%,IC score,Ki-67,and pathologic grading.Conclusion CD8+ T lymphocytes inhibited proliferation and metastasis of Luminal-type breast cancer,and PD-L1 expression in TILs,PR%,Ki-67,and pathologic grade had predictive value for survival prognosis of Luminal-type breast cancer patients.
Luminal breast cancerPD-L1tumor cellTumor infiltrating lymphocytesPredictive value
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