Objective To study the serum Protein Induced by Vitamin K Absence or Antagonist-Ⅱ(PIVKA-Ⅱ)and Alpha-fetoprotein(AFP)levels in patients with primary liver cancer and their clinical significance.Methods The clinical data of 68 patients with primary liver cancer ad-mitted to our hospital from January 2019 to October 2023 were analyzed as the liver cancer group,and 50 patients with hepatitis B cirrhosis admitted during the same period were selected as the cirrhosis group,50 patients with chronic hepatitis B as the hepatitis group,and 50 healthy people as the control group.The serum PIVKA-Ⅱ and AFP levels in the four groups were compared,and serum PIVKA-Ⅱ and AFP levels in patients with differ-ent pathological characteristics in the liver cancer group were compared.Results The serum PIVKA-Ⅱ and AFP levels in liver cancer group were higher than those in cirrhosis group,hepatitis group and control group,with statistical significance(P＜0.05).There was no statistical significance in serum PIVKA-Ⅱ between cirrhosis group,hepatitis group and control group(P＞0.05),and there was no significant difference in serum AFP between cirrhosis group and hepatitis group(P＞0.05).Comparison of patients with different TNM stage in liver cancer group,liver function Child grade,tumor diameter,number of lesions,lymph node metastasis and microvascular invasion in HCC group,there was statistical significance(P＜0.05).Conclusion Serum PIVKA-Ⅱ and AFP were significantly increased in patients with primary liver cancer,which could reflect the severity of the pa-tient's disease and have good clinical application value.
Primary liver cancerProtein Induced by Vitamin K Absence or Antagonist-ⅡAlpha-fetoproteinPathological features
NETL
NSTL
维普
万方数据
