Prognostic analysis of thyroid hormone in patients with moderate to severe craniocerebral injury
Objective To detect thyroid hormone in patients with moderate to severe traumatic brain injury(TBI)and to reveal its prognostic value.Methods The thyroid hormone of 52 patients with moderate or severe TBI admitted to neurosurgery department of our hospital from January 2017 to January 2022 was analyzed retrospectively.The patients were followed up 6 months after discharge and were divided into two groups accord-ing to the Glasgow Prognosis score(GOS score):poor prognosis group and good prognosis group.The relationship between thyroid hormone and progno-sis was analyzed.Results There were 21 patients in the good prognosis group and 31 patients in the poor prognosis group,both of which had sta-tistical significance in GCS score(P＜0.05),other gender,age,cause of the disease had no significant statistical significance(P＜0.05).FT3 and FT4 of the poor prognosis group were 2.82±0.33 pmol/L and 12.17±2.34 pmol/L respectively.FT3 and FT4 of the good prognosis group were 3.20±0.30 pmol/L and 13.74±1.78 pmol/L respectively.There was a statistical difference(P＜0.05).In multivariate analysis,GCS score was low(OR=1.520,95%CI:1.080-2.130,P=0.015),FT3 was low(OR=14.967,95%CI:1.368-163.776,P=0.027),and FT4 was low(OR=1.421,95%CI:1.003-2.014,P=0.048)were in-dependent factors for poor prognosis of TBI(P＜0.05).GCS score:AUC was 0.786(95%CI:0.662-0.909,P=0.001).FT3:AUC was 0.812(95%CI:0.694-0.929,P＜0.001).FT4:AUC was 0.722(95%CI:0.5855-0.859,P=0.007).GCS score,FT3 and FT4 were higher in predicting poor prognosis of TBI patients.Conclusion This study found that low FT3 and low FT4 are independent factors for poor prognosis of moderate and severe TBI,and have certain significance for predicting prognosis of moderate and severe TBI.
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