Objective To observe the hemolytic effect of different doses of urokinase on ventricular hemorrhage casting.Methods 200 pa-tients with ventricular hemorrhage were selected and randomly divided into treatment group 1,treatment group 2,treatment group 3,treatment group 4,and treatment group 5.All patients were underwent bilateral ventricular minimally invasive puncture and drainage,and perfused with 20000U,40000U,60000U,80000U,100000U urokinase in the treatment group 1,treatment group 2,treatment group 3,treatment group 4,treatment group 5,respectively.After perfusion,the drainage tube was clamped for 1 hour and open it,and cranial CT scan was performed the next day.The output of ventricular hematoma in five groups were observed and compared.Results The hematoma output in treatment group 1 was 8.28±1.06 mL,in treat-ment group 2 was 10.70±2.08 mL,in treatment group 3 was 14.28±2.34 mL,in treatment group 4 was 15.83±2.78 mL,and in treatment group 5 was 19.93±2.97 mL.The incidence of intracranial infection in treatment Group 1 was 17.95%,in treatment Group 2 was 5.00%,in treatment Group 3 was 2.63%,in treatment Group 4 was 5.00%,and in treatment Group 5 was 2.56%.The incidence of intracranial infection was highest in treatment group 1,and the difference was statistically significant.The recurrence rate of treatment group 1 was 0,treatment group 2 was 0,treatment group 3 was 2.63%,treatment group 4 was 10.00%,and treatment group 5 was 15.38%.As the dosage of urokinase increases,the incidence of rebleeding increased,and the difference was statistically significant.Conclusion The use of 40000U to 60000U urokinase is most suitable for patients with ventricular hem-orrhage,with minimal complications,and is suitable for clinical promotion.
Different doses of urokinaseVentricular hemorrhagePuncture and drainage
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