Correlation between serum bone metabolism indexes and delayed bone healing in patients with traumatic fracture after operation
Objective To explore the correlation between postoperative serum bone metabolism indexes and delayed bone healing in patients with traumatic fracture.Methods 54 patients with delayed healing of traumatic fractures in our hospital from January 2022 to December 2023 were retrospectively analyzed as the study group,and 54 patients with normal healing of traumatic fractures were selected as the control group.The levels of serum bone metabolism indicators[type 1 collagen N-terminal extension peptide(P1NP),osteocalcin(OST)and β-collagen degradation product(β-CTx)]in both group were compared,and the effects of serum P1NP,OST and β-CTx on postoperative bone of patients with traumatic fracture were analyzed by using the curve of receiver's working characteristics(ROC).Results The levels of serum P1NP,OST and β-CTx in research group and control group were higher than those in the same group before and after surgery(P＜0.05),and the levels of serum P1NP,OST and β-CTx in control group were higher than those in research group at the same time(P＜0.05).ROC curve analysis showed that the areas under the curve of serum P1NP,OST,β-CTx levels and combined indexes for predicting the delayed bone healing after traumatic fracture were 0.734 0.729,0.705 and 0.865.Conclusion Bone metabolism may have some influence on postoperative bone healing in patients with traumatic fracture,the levels of serum P1NP,OST and β-CTx can be comprehensively measured in clinic to predict the risk of delayed bone healing in patients with traumatic fracture.
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