Correlation of miR-152 and VEGF levels with recurrence after hysteroscopic polyp electrodesiccation
Objective To investigate the correlation between miR-152 and vascular endothelial growth factor(VEGF)levels and recurrence after hysteroscopic polypectomy.Methods 130 patients who came to our hospital for hysteroscopic polypectomy from August 2020 to December 2022 were retrospectively analyzed as the inclusion subjects,and were divided into the recurrence group(n=26)and the non-recurrence group(n=104)according to whether the polyps recurred within 1 year after the operation.Baseline data,miR-152,VEGF,sex hormones and the degree of in-flammatory response were recorded and compared between the two groups,and correlation analysis was performed using Spearman's method,and lo-gistic multifactorial analysis was used to analyze the relevant factors affecting recurrence.Results The level of miR-152 was lower in the recur-rence group than that in the non-recurrence group,and the levels of VEGF and interleukin-6(IL-6)were higher than that in the non-recurrence group(P<0.05).miR-152 was negatively correlated with recurrence(r=-0.381,P<0.05)and VEGF was positively correlated with recurrence(r=0.388,P<0.05).The levels of follicle stimulating hormone(FSH),luteinizing hormone(LH)and estradiol(E2)were higher in the relapse group than those in the non-relapse group(P<0.05).Logistic analysis results concluded that small miR-152 levels,high polyp diameter,VEGF,IL-6 and E2 levels were the relevant factors affecting the patients'postoperative recurrence.Conclusion The levels of miR-152 and VEGF were strongly associated with recurrence after hysteroscopic polypectomy,and it was found that high polyp diameter,IL-6 and E2 levels also increased the risk of postoperative re-currence in patients.
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