Anaylsis of the factors influencing early mortality in severe traumatic brain injury
Objective To investigate the factors influencing early mortality in severe traumatic brain injury.Methods A total of 117 patients with severe traumatic head injury diagnosed and treated in our hospital from January 2022 to November 2022 were enrolled as research subjects,and they were divided into two groups according to death and survival,including 63 cases in the survival group and 54 cases in the death group.The relevant clinical data of patients with severe craniocerebral injury were collected,and the risk factors for early death of patients with severe craniocerebral injury were analyzed by x2 test,t-test,univariate analysis and multivariate binary logistic regression.Results Age,Glasgow Coma Score(GCS)on admission,herniation,pupil size,blood glucose immediately upon admission,lactate dehydrogenase,creatine kinase,creatine kinase isoenzyme(CKMB),creatinine,prothrombin time,partially activated thromboplastin time,thrombin time,international normalized ratio(INR),fibrinogen,albumin were associated with early mortality in patients with severe head injury analyzed by univariate analysis(P＜0.05).Age,GCS score,lactate dehydrogenase and CKMB were independent risk factors for early mortality in severe TBI patients analyzed by multivariate logistic regression analysis(P＜0.05).ROC curve analysis yielded area under the curve(AUC)values of 0.646 for age,0.792 for GCS score,0.608 for lactate dehydrogenase,0.713 for CKMB,and 0.950 for the combined prediction of early mortality.Sensitivity and specificity at the optimal cutoff values were as follows:age(44.4％,84.1％),GCS score(60.3％,88.9％),lactate dehydrogenase(72.2％,52.4％),CKMB(70.4％,65.1％),and combined prediction(81.5％,96.8％).Conclusion Age,GCS score,lactate dehydrogenase,and CKMB are independent risk factors associated with early death in patients with severe traumatic head injury,and these indicators together is valuable for studying the early death in patients with severe traumatic head injury.
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