Efficacy of 3％ diquafosol sodium in the treatment of dry eye complications in diabetic patients with cataract
Objective To investigate and analyze the effect of 3％diquafosol sodium on dry eye complications in diabetic patients with cataract after operation.Methods A total of 82 patients with diabetes combined with cataract surgery admitted to our hospital from August 2022 to December 2023 were selected in this study,and were divide into the control group(n=41)and experimental group(n=41)according to the random number table method.The patients in he control group were treated with 0.3％sodium hyaluronate eye drops and in the experimental group were treated with 3％diquifosol eye drops,and all patients were treated for 3 months.The changes of ocular surface Disease Index Scale(OSDI)score,tear film stability[break-up time(BUT),corneal fluorescein staining(FL)score]and inflammatory index[interleukin-1 β(IL-1β),interleukin-18(IL-18)]were compared between the two groups before treatment and 3 months after treatment.Results The OSDI scores of the experimental group were lower than those of the control group at 3 months after treatment(P＜0.05).After 3 months of treatment,the BUT of the experimental group was higher than that of the control group,and the FL score was lower than that of the control group(P＜0.05).The levels of IL-1β and IL-18 in the experimental group were lower than those in the control group at 3 months after treatment(P＜0.05).Conclusion The clinical effect of 3％diquafosone sodium in the treatment of dry eye complications in patients with diabetes complicated with cataract after surgery is obvious,which can improve the stability of tear film and reduce the expression of inflammatory factors,and is worth promoting.
Diabetes mellitusCataractsDiquafosol sodiumDry eye complicationsTear film stability
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