Study on the efficacy of naproxat mesylate for injection in continuous renal replacement therapy for acute kidney injury
Objective To investigate the efficacy of namostat mesylate(UM)for injection in continuous renal replacement therapy(CRRT)for acute kidney injury(AKI).Methods 76 patients with acute kidney injury admitted to our hospital from January 2023 to January 2024 were select-ed and divided into control group(n=38)and study group(n=38)according to random number table method,the patients in the control group were treated with local citric acid(RCA),and in the study group were treated with UM.The renal function indexes(uric acid,urea nitrogen,serum creati-nine),coagulation indexes(platelet count,fibrinogen,prothrombin time,activated partial prothrombin time),serum potassium,calcium and sodium lev-els were compared between the two groups before and 3 days after treatment.The adverse reactions and the average useful life of the filter during CR-RT treatment were assessed.Results There were no differences in renal function index,coagulation index,serum potassium,calcium and sodium ion levels between the two groups before treatment(P＞0.05).After treatment,renal function index and platelet count were decreased compared with before treatment(P＜0.05),fibrinogen,prothrombin time and activated partial prothrombin time were increased compared with before treatment(P＜0.05),and there was no difference between groups(P＞0.05).The serum concentrations of potassium,calcium and sodium in the study group after treatment were not different from those before treatment(P＞0.05),while the serum calcium in the control group after treatment was lower than that be-fore treatment(P＜0.05),and serum sodium was higher than that before treatment(P＜0.05).The total incidence of adverse reactions in the study group was lower than that in the control group(P＜0.05).The filter service life of the control group and the study group was(23.08±3.29)h compared with(23.43±3.04)h(P＞0.05).Conclusion In the treatment of acute renal injury CRRT,UM for injection has little effect on coagulation function,potas-sium,calcium and sodium ions,and can promote the recovery of renal function.Compared with RCA,UM for injection cannot prolong the service life of the filter,but it has higher safety.
Acute kidney injuryContinuous renal replacement therapyNaphthalmostat mesylate for injTopical citric acid for anticoagulation
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