Analysis of changes in tumor markers and inflammation after radical surgery for cervical cancer and the relationship with prognosis
Objective To investigate the relationship between prognosis and changes in tumor markers and inflammation in patients after rad-ical surgery for cervical cancer.Methods The clinical data of 72 patients with cervical cancer and underwent radical surgery who admitted to our hospital from July 2020 to July 2023 were retrospectively analyzed,and divided into the group with good prognosis (n=55) and the group with poor prognosis (n=17).The baseline data,tumor markers,inflammation and coagulation were recorded and compared between the two groups,and analyzed by Logistic multifactorial analysis.Results Before surgery,the level of alpha-fetoprotein (AFP) was lower in the worse prognosis group than that in the good prognosis group,and the levels of carcinoembryonic antigen (CEA),cancer antigen 199 (CA199),C-reactive protein (CRP),neutrophil-to-lymphocyte ratio (NLR),lymphocyte-to-monocyte ratio (LMR),and D-dimer (D-D) were higher than those in the good prognosis group (P<0.05).Lo-gistic regression analysis showed that the presence of lymph node metastasis,high preoperative CEA,NLR and D-D levels were all relevant factors af-fecting the occurrence of poor prognosis in patients (P<0.05).Conclusion Patients with lymph node metastasis or high levels of CEA,NLR and D-D before surgery are more likely to have a poor prognosis after radical cervical cancer surgery,so this group needs to be given focused attention and tar-geted interventions to improve the quality of patient prognosis.
Radical cervical cancer surgeryTumor markersInflammationPrognosisInfluencing factors
万方数据
维普
