Changes and clinical significance of serum hs-CRP/ALB and NLR after colon cancer surgery
Objective To investigate the changes in serum high-sensitivity C-reactive protein/albumin ratio (hs-CRP/ALB) and neutrophil/lymphocyte ratio (NLR) after colon cancer surgery,and their predictive value for anastomotic fistula (AL).Methods A retrospective analysis was conducted on 68 colon cancer patients admitted to our hospital from March 2021 to March 2024.The patients were divided into the AL group (n=10) and the non AL group (n=58) based on whether they developed AL after surgery.The levels of hs-CRP/ALB and NLR were compared between the two groups before surgery,on the first day after surgery,and on the third day after surgery,the receiver operating curve (ROC) was used to analyze the predictive value of hs-CRP/ALB and NLR for AL.Results There was no significant difference in preoperative hs-CRP/ALB and NLR between the two groups (P>0.05).On the first and third day after surgery,the hs-CRP/ALB and NLR of both groups were higher than before surgery (P<0.05),the hs-CRP/ALB and NLR of the AL group were higher than those of the non AL group after surgery (P<0.05).On the third day after surgery,the hs-CRP/ALB and NLR of the AL group were higher than those of the first day after surgery (P<0.05),while on the third day after surgery,the hs-CRP/ALB and NLR of the non AL group were lower than those of the first day after surgery (P<0.05).The ROC curve results showed that the area under the curve of serum hs-CRP/ALB,NLR levels and combined indicators for predicting postoperative AL in colon cancer was 0.736,0.759,and 0.847.The area under the curve of combined examination was larger than that of hs-CRP/ALB and NLR detected separately,with sensitivities of 85.4％,87.9％,and 85.3％,specificities of 75.3％,71.4％,and 80.1％,and cutoff values of hs-CRP/ALB and NLR of 2.69 and 12.67,respectively.Conclusion The serum hs-CRP/ALB and NLR values after colon cancer surgery were higher than those before surgery,and the serum hs-CRP/ALB and NLR values on the third day after surgery have certain predictive value for AL.
万方数据
维普
