Effect of PEG dispersity and structure on the stability of PEG micelles in BSA solutions
The in vitro stability of polyethylene glycol(PEG)-modified micelles is a crucial factor for their application as nanocarriers for drug delivery.A series of amphiphilic polymers were synthesized by using PEGs with different dispersities and structures,combined with octadecanoic acid,tetradecanoic acid,1,2-distearoyl-sn-glycero-3-phosphoethanolamine,cholesterol,vitamin E succinate,N,N-ditetradecylamine,and the anticancer drug paclitaxel.The study investigated the effects of PEG's dispersity and structure on the critical micelle concentration(CMC),particle size,and stability in bovine serum albumin(BSA)solutions under the same hydrophobic segment conditions.The results show that the dispersion of PEG has little effect on the CMC and particle size of linear PEGylated micelles,while the branched PEGylated micelles are significantly smaller in CMC and particle size than linear PEGylated micelles;the stability of branched PEGylated micelles in BSA solutions is superior to that of their linear monodisperse counterparts,while the stability of polydisperse PEGylated micelles is unsatisfactory.PEG structure and dispersity affect the in vitro stability of micelles.The results of this paper provide important reference for the development of drug delivery systems with monodisperse PEG micelles.
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