摘要
针刺是缺血性脑卒中(IS)的有效治疗方法,在IS后的神经及功能康复中发挥着关键作用.针刺可改善IS后各种并发症的临床症状,包括运动功能障碍、吞咽障碍、言语障碍、认知障碍、抑郁、失眠、疲劳等.然而,针刺治疗IS的机制尚不清楚.现有证据表明,针刺可能通过调节神经可塑性(神经发生和突触发生)、血管生成、细胞增殖和凋亡以及调节氧化应激、炎症及免疫等途径发挥神经保护作用.未来应通过关注临床和基础研究设计,增加样本量,规范和量化针刺操作标准,运用多学科交叉技术和方法,系统探索针刺干预IS的关键靶点,揭示针刺治疗IS的疗效和机制,完善针刺干预IS的高质量循证体系.
Abstract
Acupuncture is an effective treatment for ischemic stroke(IS)and plays a key role in neurological rehabilitation after IS.Acupuncture can improve the clinical symptoms of various complications after IS,including motor dysfunction,swallowing disorders,speech disorders,cognitive impairment,depression,insomnia,and fatigue.However,the mechanisms underlying the effects of acupuncture in IS remain unclear.Available evidence suggests that acupuncture may exert neuroprotective effects through neuroplasticity(neurogenesis and synaptogenesis),angiogenesis,cell proliferation and apoptosis,and regulation of oxidative stress,inflammation,and immunity.Further studies should be conducted to improve the high-quality evidence-based system of acupuncture intervention for IS,by focusing on the clinical and basic research design,increasing the sample size,standardizing and quantifying the standards of acupuncture operations,using multidisciplinary techniques and methods to systematically explore the key targets of acupuncture intervention for IS,and reveal the efficacy and mechanism of acupuncture in the treatment of IS.
基金项目
Ministry of Science and Technology of the People's Republic of China,National Key Research and Development Program(2018YFC1706001)
Tianjin Municipal Science and Technology Bureau,Tianjin Science and Technology Plan Project(21JCQNJC01560)
Tianjin Education Commission scientific research project(2022KJ170)
Tianjin Municipal Education commission()
Tianjin Graduate Research Innovation Project(Service Industry Project)(2022BKYZ046)
Tianjin University of Traditional Chinese Medicine()
Tianjin University of Traditional Chinese Medicine Graduate Research Innovation Project(YJSKC-20222002)
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Exploration and Innovation Project(YB202112)
万方数据