电针针对免疫系统缓解脓毒症

Electroacupuncture targeting the immune system to alleviate sepsis

方梦悦 ¹蓝渝叶 ²李熳 ²李晨楠 ²徐斌 ³马艳 ⁴陈爱玲 ⁵景向红 ⁶余玲玲⁷

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作者信息

1. 华中科技大学同济医学院附属同济医院,湖北
2. 华中科技大学同济医学院基础医学院,湖北
3. 南京中医药大学针药结合教育部重点实验室,南京
4. 华中科技大学同济医学院附属武汉市第一医院,武汉
5. 泰国皇太后大学整合医学院,泰国
6. 中国中医科学院针灸研究所,北京
7. 华中科技大学同济医学院附属同济医院中西医结合研究所,湖北
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摘要

脓毒症是一种危及生命的炎症综合征,发病率和死亡率很高.然而,脓毒症的治疗选择仍然局限于重症监护室的常规治疗,并且需要提高败血症存活率的有效疗法.免疫紊乱在败血症的病理学中起着至关重要的作用,并与长期炎症、感染易感性和死亡有关.因此,许多研究人员将注意力集中在免疫调节治疗败血症的潜在益处上.电针在临床上应用多年,在治疗传染病方面显示出优势.在过去的几十年里,我们对电针治疗败血症的疗效和机制的理解有了长足的发展.我们检索了2010-2023年关于“CNKI、万方数据、VIP数据库、PubMed和Ingenta Connect”的文献,使用关键词“败血症”“脓毒症”和“电针”,检索了336个来源.最后,我们纳入了82项针对免疫系统的研究,以确定EA对败血症的抗炎和免疫调节作用.在这篇综述中,我们发现电针通过多种机制,如激活胆碱能抗炎通路(CAP)、迷走神经-肾上腺轴、抑制核因子Kappa-B(NF-κB)信号通路,在缓解脓毒性炎症、改善免疫功能和减轻相关多器官损伤方面具有临床益处,信号转导子和转录激活子(STAT)信号通路以及免疫细胞功能的改善.因此,电针治疗脓毒症可能是一种很有前途的补充疗法.我们还希望这些数据将有助于进一步研究EA在败血症中的作用.

Abstract

Sepsis is a life-threatening inflammatory syndrome with high morbidity and mortality rates.However,options for sepsis are still limited to general treatment in intensive care units(ICUs),and effective therapies that improve sepsis survival are required.Immune disturbances play a vital role in the pathology of sepsis and are associated with protracted inflammation,susceptibility to infections,and death.Therefore,many investigators have focused on the potential benefits of immunomodulation therapy for sepsis.Electroacupuncture(EA)has been practiced in clinics for many years and has shown advantages in treating infectious diseases.Over the last few decades,our understanding of the efficacy and mechanisms of EA in sepsis has undergone considerable developments.We searched the literature regarding"CNKI,Wan Fang Data,VIP Database,PubMed,and Ingenta Connect"from 2010 to 2023,using the keywords"sepsis""septic"and"electroacupuncture"and 336 sources were searched.Finally,we included 82 studies that targeted the immune system to determine EA's anti-inflammatory and immunomodulatory effects on sepsis.In this review,we found that EA has clinical benefits in relieving septic inflammation,improving immune function,and attenuating related multi-organ injury through several mechanisms,such as activation of the cholinergic anti-inflammatory pathway(CAP),vagal-adrenal axis,inhibition of the nuclear factor Kappa-B(NF-κB)signaling pathway,signal transducers and activators of transcription(STAT)signaling pathway,and improvement of immune cell function.Therefore,EA may be a promising complementary therapy for sepsis treatment.We also expect these data will contribute to further studies on EA in sepsis.

关键词

胆碱能抗炎通路/电针/NF-κB/脓毒症/信号转导和转录激活因子,迷走神经-肾上腺轴

Key words

Cholinergic anti-inflammatory pathway/Electroacupuncture/Nuclear factor Kappa-B/Sepsis/Signal transducers and activators of transcription/Vagal-adrenal axis

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基金项目

National Key Research and Development Program(2022YFC3500704)

National Natural Science Foundation of China(82174500)

National Natural Science Foundation of China(82004491)

出版年

2024

针灸和草药(英文)

天津中医药大学，中华中医药学会

针灸和草药(英文)

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参考文献量129

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