于共抑制受体调节T细胞免疫理论探讨"扶正(Fú Zhèng)"治疗类风湿关节炎的新视角

New perspective on the treatment of rheumatic arthritis based on"strengthening body resistance(Fú Zhèng)"in the theory of co-inhibitory receptor-regulated T-cell immunity

徐亦非 ¹钟丽丹 ²梁倩倩 ³徐浩⁴

扫码查看

作者信息

1. 上海中医药大学附属龙华医院,上海
2. 南洋理工大学生物科学学院生物医学与中医学系,新加坡
3. 上海中医药大学附属龙华医院,上海;上海中医药大学脊柱病研究所,上海;上海中医药大筋骨理论与治疗教育部重点实验室
4. 上海中医药大学附属龙华医院,上海;上海中医药大学脊柱病研究所,上海
折叠

摘要

共抑制受体是T细胞功能的关键调节器,在调节免疫耐受和自身免疫之间的平衡方面发挥着关键作用.在自身免疫疾病模型中被发现的CTLA-4、PD-1、TIM-3和TIGIT均属于共抑制受体,它们是免疫调节不可或缺的组成部分.在这些模型中,它们的阻断或缺失会导致自身免疫性疾病的诱发或加重.此外,研究者还发现,淋巴细胞上的共抑制受体有可能影响慢性炎症的预后.因此,阻断共抑制受体已成为抑制难治性炎症疾病(尤其是类风湿性关节炎)的一种新型治疗方法.从中医理论的角度来看,基于“扶正”理论的类风湿关节炎治疗可理解为通过调节共抑制受体来调节机体的免疫功能,从而对抗慢性炎症.本文简要概述了共抑制受体在抗炎过程中的作用,并探讨了共抑制受体干预治疗类风湿性关节炎的研究前景.该探索将“扶正”理论与相关中药方剂相结合.

Abstract

Co-inhibitory receptors serve as crucial regulators of T-cell function,playing a pivotal role in modulating the delicate balance between immune tolerance and autoimmunity.Initially identified in autoimmune disease models,co-inhibitory receptors,including CTLA-4,PD-1,TIM-3,and TIGIT,were found to be integral to immune regulation.Their blockade or absence in these models resulted in the induction or exacerbation of autoimmune diseases.Additionally,scholars have observed that co-inhibitory receptors on lymphocytes hold the potential to influence the prognosis in the context of chronic inflammation.Consequently,the blocking of co-suppressor receptors has emerged as a novel therapeutic approach for inhibiting refractory inflammatory diseases,particularly rheumatoid arthritis.From the standpoint of traditional Chinese medicine(TCM),the treatment of rheumatoid arthritis based on the"strengthening body resistance(Fú Zhèng)"theory can be construed as the regulation of co-suppressor receptors to modulate the body's immune function in combating chronic inflammation.This article provides a succinct overview of the role of co-suppressor receptors in anti-inflammatory processes and explores the research prospects of co-suppressor receptor intervention in the treatment of rheumatoid arthritis.The exploration integrates the"strengthening body resistance(Fú Zhèng)"theory with relevant Chinese medicine formulations.

关键词

中西医结合/共抑制受体/扶正理论/类风湿性关节炎/T细胞耗竭

Key words

Combination of Chinese and Western Medicine/Co-inhibitory receptors/Rheumatic arthritis/T-cell exhaustion

引用本文复制引用

基金项目

National Innovation and Entrepreneurship Training Program for College Students(202310268058)

Exploration of the Mechanism on Therapeutic Efficacy of Gulong Capsules in Treatment of Osteoarthritis from the Perspective of M(E4-H23066)

出版年

2024

针灸和草药(英文)

天津中医药大学，中华中医药学会

针灸和草药(英文)

ISSN：

参考文献量43

段落导航