使用三种中药配方提高结直肠癌患者术后生存率的回顾性队列研究:基于1361例患者的证据

Retrospective cohort study on the postoperative survival rate enhancement of patients with colorectal cancer using three traditional Chinese medicine formulations:evidence from 1,361 cases

赵凯龙 ¹苏小敏 ²庞雯雯 ³王弋嘉 ⁴李洪洲 ⁵张轶 ⁶金磊鑫 ⁷薛军 ⁸梁卫政 ⁸冯志强 ⁷韩秋荣 ⁷姚瑶 ⁷陈天义 ⁷张庆怀 ⁹张锡朋 ⁹郑文科 ¹⁰张春泽⁹

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作者信息

1. 南开大学医学院,天津;天津市人民医院结直肠外科,天津
2. 南开大学医学院免疫学系,南开大学,天津
3. 天津市人民医院临床检验科,天津
4. 天津市人民医院肿瘤分子医学实验室,天津
5. 天津市人民医院消化内科,天津
6. 天津市人民医院结直肠外科,天津;天津肛肠研究所,天津
7. 天津市人民医院结直肠外科,天津;天津中医药大学中西医结合学院,天津
8. 河北北方学院附属第一医院普通外科,张家口
9. 天津市人民医院结直肠外科,天津;天津肛肠研究所,天津;天津市人民医院转化医学研究所,天津
10. 天津中医药大学循证医学中心,天津
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摘要

本研究旨在评估西黄胶囊、平消胶囊和紫龙金片对结直肠癌患者术后5年总生存率(OS)和无病生存率(DFS)的影响,以提供中医药治疗结直肠癌的疗效证据.采用回顾性研究方法,分析了天津市人民医院医疗中心1361名患者的数据.通过Kaplan-Meier生存分析和Cox比例风险模型评估药物组与对照组的生存差异,并采用倾向得分匹配以平衡患者基线特征.研究结果显示,在倾向得分匹配前,西黄胶囊能显著提高患者5年OS(79.9％vs.81.4％,P=0.048)和DFS(74.9％vs.79.5％,P=0.0046).倾向得分匹配后,西黄胶囊组的5年OS(74.8％vs.78.3％,P=0.0084)和DFS(72.7％vs.78.9％,P=0.008)同样显著提高.平消胶囊组在匹配后也显示出5年OS(77.2％vs.84.0％,P=0.0383)和DFS(69.9％vs.80.0％,P=0.0157)的显著改善.紫龙金片组在匹配后则在2年OS(84.2％vs.93.1％,P=0.0390)和1年DFS(88.2％vs.92.0％,P=0.0320)上显示出改善.综上所述,西黄胶囊和平消胶囊能显著提高结直肠癌患者术后5年OS和DFS,而紫龙金片则在术后短期内改善了患者的OS和DFS.

Abstract

Background:Prior studies have affirmed the safety and effectiveness of traditional Chinese medicine in treating colorectal cancer patients.However,definitive evidence regarding whether traditional Chinese medicine can significantly enhance the survival of colorectal cancer patients remains elusive.This study seeks to provide conclusive insights by examining the postoperative administration of Xihuang capsules,Pingxiao capsules,and Zilongjin tablets and its impact on the 5-year overall survival(OS)and disease-free survival(DFS)rates among colorectal cancer patients.Methods:A retrospective study was conducted,involving 1,361 patients selected from the medical center.This retrospective study was carried out at a medical center in Tianjin,China.We assessed differences in postoperative OS and DFS between the control group and the medication group using Kaplan-Meier survival analysis and Cox proportional hazards modeling.Additionally,propensity score matching was used to mitigate imbalances in baseline characteristics among patients.Results:Before propensity score matching,Xihuang capsules could prolong the 5-year OS(79.9％vs.81.4％,P=0.0480)and 5-year DFS(74.9％vs.79.5％,P=0.0046)of patients after surgery.Similar conclusions were obtained after propensity score matching:OS(74.8％vs.78.3％,P=0.0084),DFS(72.7％vs.78.9％,P=0.008).Patients taking Pingxiao capsules showed improved 5-year OS(77.2％vs.84.0％,P=0.0383)and 5-year DFS(69.9％vs.80.0％,P=0.0157)after propensity score matching.Patients taking Zilongjin tablets showed improvement in the 2-year OS(84.2％vs.93.1％,P=0.0390)and 1-year DFS(88.2％vs.92.0％,P=0.0320)after propensity score matching.Conclusion:Xihuang capsules and Pingxiao capsules significantly improved the 5-year OS and DFS of patients with colorectal cancer after surgery.Zilongjin tablets showed improvement in the 2-year OS and 1-year DFS after surgery for patients.

关键词

中医药/总生存率/无病生存率/结直肠癌

Key words

Colorectal cancer/Disease-free survival/Traditional Chinese medicine/Overall survival

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基金项目

Key Research Project of Tianjin Science and Technology Support Program(19YFZCSY00420)

Tianjin Natural Science Foundation(21JCZDJC00060)

Tianjin Natural Science Foundation(21JCYBJC00180)

Tianjin Natural Science Foundation(21JCYBJC00340)

Tianjin Key Medical Discipline Construction Project(TJYXZDXK-044A)

Hospital Management Research Project of Tianjin Hospital Association(2019ZZ07)

Beijing-Tianjin-Hebei Basic Research Cooperation Project(23JCZXJC00390)

出版年

2024

针灸和草药(英文)

天津中医药大学，中华中医药学会

针灸和草药(英文)

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参考文献量18

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