Protective Effect of Euphausia superba Active Peptide on Cell Models of Non-Alcoholic Fatty Liver Disease
In this study,the Euphausia superba peptides were selected as experimental materials.NAFLD model of human hepatocellular carcinoma cells(HepG2)was established by oleic acid(OA),which was used to screen protective peptides,among which Oligopeptide Val-Glu could significantly reduce the intracellular TG content(P＜0.001).Then,the lipid-lowering activity of Oligopeptide Val-Glu was evaluated,and we observed that Val-Glu could significantly reduce the cellular lipid deposition in HepG2 cells.Furthermore,the antioxi-dant activity of Val-Glu was evaluated.The results showed that Val-Glu could inhibit the production of reac-tive oxygen species(ROS),significantly increase catalase(CAT),superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px),and reduce the content of lipid peroxidation product malondialdehyde(MDA).
万方数据
维普
