In this study,the Euphausia superba peptides were selected as experimental materials.NAFLD model of human hepatocellular carcinoma cells(HepG2)was established by oleic acid(OA),which was used to screen protective peptides,among which Oligopeptide Val-Glu could significantly reduce the intracellular TG content(P＜0.001).Then,the lipid-lowering activity of Oligopeptide Val-Glu was evaluated,and we observed that Val-Glu could significantly reduce the cellular lipid deposition in HepG2 cells.Furthermore,the antioxi-dant activity of Val-Glu was evaluated.The results showed that Val-Glu could inhibit the production of reac-tive oxygen species(ROS),significantly increase catalase(CAT),superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px),and reduce the content of lipid peroxidation product malondialdehyde(MDA).
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