Protective Effect of Sodium Butyrate on Intestinal Barrier Injury in Weaning Stress Rats
The purpose of this study was to investigate the protective effect of sodium butyrate(NaB)on intestinal barrier injury in weaning stress rats and the effect of sodium butyrate on intestinal flora.The weaning stress model of SD rats was established by intragastric administration of 120 mmol·L-1 NaB for 14 days.The results showed that sodium butyrate alleviated colonic mucosal injury and increased the thickness of the in-testinal mucus layer.Significantly reduced serum DAO and LPS levels;the mRNA expression levels of ZO-1,Claudin-1,and mucin-2 in colon tissue were significantly increased.16S rRNA high-throughput sequencing results showed that sodium butyrate could regulate the diversity and composition of intestinal flora in weaned rats,and significantly reduce the abundance of Clostridium_sensu_sticto_1,Akkermansia and Staphylococcus,and significantly increase the abundance of Romboutsia,Lactobacillu and Turicibacter.In summary,sodium butyrate can alleviate mucosal barrier damage in weaned stress rats and improve intestinal microecology in weaned stress rats,thereby effectively protecting intestinal barrier function.
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