Objective To explore the functional connection between bilateral amygdala and whole brain in adolescent depression patients with attempted suicide by resting-state functional magnetic resonance imaging(rs-fMRI).Methods A total of 36 major depressive disorder(MDD)adolescents with suicide attempt history(the sMDD group),36 MDD adolescents without suicide attempt history(the nsMDD group),and 35 healthy subjects(the HC group)were selected for rs-fMRI scan.We selected the bilateral amygdala as the seed point and calculated the temporal correlation between them and all the voxels in the whole brain.Finally,the Resting-state functional connectivity(rsFC)with significant differences among the three groups and the correlation between it and clinical scales were explored.Results The rsFC with statistically significant differences among the three groups:left amygdala-right middle temporal gyrus;left amygdala-right insula;right amygdala-right middle frontal gyrus(P<0.05).Partial correlation analysis showed that,in the sMDD group,the rsFC of the right amygdala-right middle frontal gyrus was significantly negatively correlated with DERS score(r=-0.521,P=0.002).Conclusion The abnormal function of the amygdala-related emotional regulation circuits in adolescent depression patients may be the potential neural mechanism of adolescent suicidal behavior.
维普
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