Objective To investigate the relationship between serum FGF-23,soluble klotho protein and carotid intima-media thickness(CIMT)in patients undergoing continuous ambulatory peritoneal dialysis(CAPD).Methods From January 2021 to April 2023,60 patients treated with CAPD in the peritoneal dialysis center of our hospital were selected as the research object.Patients with CIMT≥1.2 mm were included in the thickening group(n=36),and patients with CIMT<1.2 mm were included in the normal group(n=24).General information and carotid ultrasound examination in both groups were compared.Cholesterol,triglyceride,high-density lipoprotein,low-density lipoprotein,scr,high-sensitivity C-reactive protein(Hs-CRP),β2-Microglobulin,parathyroid hormone,homocysteine,soluble Klotho protein,serum FGF-23 and other indicators were determination respectively.Results The age,serum FGF-23,and Hs-CRP in the CIMT thickening group compared the normal group were significantly higher(P<0.05).In the CIMT thickening group,the serum soluble Klotho protein compared the CIMT normal group were significantly lower(P<0.05).In CIMT thickening group,the CIMT level and the atherosclerotic plaque proportion compared the CIMT normal group were significantly higher(P<0.05).In both groups,the proportion of carotid artery stenosis was of no statistically significant difference(P>0.05).The logistic regression analysis showed that age,serum FGF-23,and Hs-CRP were independent risk factors for CIMT thickening in CAPD patients,while soluble Klotho protein was a protective factor for CIMT thickening in CAPD patients.Conclusion CAPD patients with CIMT thickening are prone to form atherosclerotic plaque.Age,serum FGF23 and high-sensitivity C-reactive protein can be considered as independent risk factors of carotid artery middle membrane thickening in CAPD patients,while Klotho protein is a protective factor.
Continuous ambulatory peritoneal dialysisCarotid intima-media thicknessSerum FGF-23Soluble Klotho protein
万方数据
维普
