Objective To investigate the effect of She Medicine-Melastoma Dodecandrum Lour Formula on inflammatory factors,neurological function recovery and life independence on the 90th day after acute ischemic stroke(AIS).Methods Patients with AIS who met the inclusion criteria and were hospitalized in the Department of Neurology of Lishui Traditional Chinese Medicine Hospital between January 2020 and January 2022 were selected and randomly divided into two groups,with 193 patients finally included.Continuous 14 days of conventional treatment(the control group)or conventional treatment plus She Medicine-Melastoma Dodecandrum Lour Formula(the treatment group).The concentrations of TNF-α,IL-1β and IL-6,National Institutes of Health Stroke Scale(NIHSS)scores and 90-day modified Rakin Scale(mRS)scores were measured on day 14 after treatment in both groups to assess the effectiveness of She Medicine-Melastoma Dodecandrum Lour Formula treatment.Early neurological deterioration,symptomatic intracranial hemorrhage and 90-day mortality were compared between the two groups to clarify the safety of She Medicine-Melastoma Dodecandrum Lour Formula.Results After 14 days of treatment,the decrease of TNF-α,IL-1β and IL-6 in the treatment group was greater than that in the control group.The NIHSS score of the treatment group was significantly lower than that of the control group at 14 days[(6.07±3.38)points VS.(7.19±3.53)points].On the 90th day,the proportion of patients in the treatment group to obtain independent living ability(mRs score≤2 points)was significantly higher than that in the control group(52.6%VS.36.7%,P<0.05),and there was statistical difference in the efficacy between the two groups.In terms of safety,there was no significant difference in early neurological deterioration(9.5%VS.11.2%),symptomatic intracranial hemorrhage(5.3%VS.6.1%)and 90-day mortality(1%VS.2%)between the two groups(P>0.05).Conclusion The medication within 72 h after AIS in the She Medicine-Melastoma Dodecandrum Lour Formula group was helpful to reduce the release of inflammatory factors,improve the life independence of AIS patients on the 90th day and promote the recovery of neurological function,thereby improving the prognosis of stroke and reducing the disability rate.
She Medicine-Melastoma Dodecandrum LourAcute ischemic strokeNeurological recovery
维普
万方数据
