Objective To analyze the application of Houpu Sanwu decoction in regulating acute gastrointestinal dysfunction patients with sepsis,explore its influence on intestinal microecology,and provide reference for formulating targeted treatment.Methods 60 cases of patients with sepsis complicated with acute gastrointestinal dysfunction who received treatment in our hospital from February 2022 to February 2023 were selected as the subjects of this study.All patients were grouped by random number table,the patients in the control group were received conventional western medicine treatment,and the patients in the observation group were treated with single flavor plus or minus Houpu Sanwu decoction on the basis of conventional treatment.Fecal samples from patients admitted to ICU 7 days after treatment were collected for high-throughput 16S rRNA gene sequencing analysis.The levels of inflammatory factors,intestinal permeability factors and immune barrier function indexes were compared before and 7 days after treatment.Results In the observation group,the relative abundance of facultative anaerobe in Firmicutes was higher,including Streptococcus,Gemella,Enterobacteriaceae,and Haemophilus.Fecal bacteria of the control group were mainly anaerobic Firmicutes,including Clostridium,Bacteroides fragilis,Veillonella,and Anaerostipes.The richness and diversity of intestinal flora in the control group were significantly lower than those in the observation group.After 7 days of treatment,the levels of serum TNF-α,hs-CRP,WBC and IL-6 in 2 groups were decreased,and the levels of serum TNF-α,hypersensitive C-reactive protein(hs-CRP),leukocyte(WBC)and IL-6 in observation group were lower than those in control group(P<0.05).The levels of intestinal permeability factor Diamine Oxidase(DAO)and D-lactic acid indexes in 2 groups were lower than before treatment,and DAO and D-lactic acid indexes in the observation group were slightly lower than the control group(P<0.05).The IgA,IgM and IgG indexes of intestinal immune barrier function in 2 groups were higher than those before treatment,and the IgA,IgM and IgG indexes in the observation group were higher than those in the control group(P<0.05).Conclusion The addition and reduction of Houpu Sanwu decoction can effectively improve the intestinal microecology of patients with acute gastrointestinal dysfunction of sepsis,reduce inflammatory response,improve the function of intestinal immune barrier,and improve the prognosis and rehabilitation quality of patients.
Intestinal microecologyHou pu Sanwu decoctionSepsisAcute gastrointestinal dysfunctionIntestinal permeabilityIntestinal immune barrier
万方数据
维普
