Objective To assess the short-term effects and safety of low-frequency repetitive transcranial magnetic stimulation(rTMS)in the treatment of primary blepharospasm(BS).Methods A total of 90 BS patients who came to our neurologic clinic from November 2019 to July 2020 were selected,who were divided into three groups according to the random number table method,namely the botulinum toxin group(the BTX group),the low-frequency rTMS group(the rTMS group),the botulinum toxin combined with the low-frequency rTMS group(the BTX+rTMS group).The patients were followed up for 12 weeks after given different treatments.We recorded the onset time and the adverse reactions of the three groups.The Jankovic rating scale(JRS)and the blepharospasm disability index(BSDI)were used to evaluate the severity of the disease.And the modified Toronto Western Spasmodic Torticollis Rating Scale(TWSTRS)efficacy scale was used to evaluate the efficacy.Results The onset time of the rTMS group and the BTX+rTMS group was much shorter than that of the BTX group,and the difference was statistically significant(P<0.05).In the first,the fourth and the twelfth weeks,the JRS scores of the three groups were lower than those before treatment,and the difference was statistically significant(P<0.05).In the fourth and the twelfth weeks,JRS scores of the BTX group and the BTX+rTMS group are lower than that of the rTMS group,the difference was statistically significant(P<0.05).At the time of fourth and twelfth weeks,the BSDI of the three groups was significantly lower compared with that before treatment,the difference was statistically significant(P<0.05).At the 12th week,the BSDI score of the BTX group and the BTX+rTMS group are much lower than the rTMS group,the difference was statistically significant(P<0.05).At the time of twelfth week,there were 7 patients(23.3%)in the BTX group with a modified TWSTRS efficacy score≥3,14 patients(46.67%)in the BTX+rTMS group,and none in the rTMS group.Conclusion Low-frequency rTMS used for the treatment of BS takes a rapid onset,and has few adverse effects,but has short maintenance time of efficacy.Combined with the BTX injection,it can significantly shorten the onset time of BS patients,and can further improve the clinical efficacy.
BlepharospasmTranscranial magnetic stimulationCurative effect
万方数据
维普
