Objective To investigate the epidemic and clinical characteristics of hand-foot-and-mouth disease(HFMD)after Enterovirus A71(EV-A71)vaccination.Methods 688 children with enterovirus infection HFMD diagnosed in the laboratory and hospitalized in Hangzhou children's Hospital from January 2018 to December 2021 were collected.Investigated and summarized the etiology and clinical characteristics of HFMD with EV-A71 vaccination history.Results There were 47 cases of HFMD with EV-A71 vaccination history(11 cases were vaccinated once and 36 cases were vaccinated twice).There were 28 males and 19 females.Age distribution:5 cases were less than 1 year old,40 cases were 1-3 year old,1 case was 3-4 year old.Clinical manifestations:47 cases were all fever with oral herpes,36 cases of herpes in the isthmus,33 cases of herpes in the hands,32 cases of herpes in the feet and buttocks.There were 25 cases of rashes on the face,neck,limbs,trunk,elbow and other parts.Among 47 cases of HFMD after vaccination,31 cases were infected by enterovirus A6(CV-A6),9 cases by enterovirus A16(CV-A16),7 cases by other enteroviruses,and 0 cases by EV-A71.The serum EV-A71 IgM antibody was positive in 14 cases,including 3 cases positive and 11 cases weakly positive.Among the 14 patients,6 received EV-A71 vaccine once and 8 received EV-A71 vaccine twice.The longest time from vaccination to infection was 12 months.Conclusion EV-A71 vaccination can effectively prevent EV-A71 infection,but it can not prevent other non EV-A71 enteroviruses.
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