Objective To investigate the clinical efficacy of fire-needing combined with 1540 nm non-ablative fractional laser in the treatment of acne.Methods Sixty patients with acne from June 2021 to December 2022 were randomly divided into the observation group and the control group,with 30 patients in each group.The control group received non-ablative fractional laser treatment,while the observation group combined with fire-needing.The scores of pores,red areas,and purple matter on the VISIA skin detector,the Acne Comprehensive Classification System(GAGS)scale,the total clinical response rate,and the Acne Disability Index(CADI)score were observed in both groups.Results In the comparison of the values of pores,red areas,and purple matter detected by VISIA,there was a statistically significant difference between the two groups after treatment in red areas,and purple matter(P<0.05).After treatment,there was a statistically significant difference between the observation group and the control group in the scores of pores,red areas,and purple matter(P<0.001).The difference in GAGS scores between the two groups after treatment was statistically significant(P=0.032).The difference in GAGS scores between the observation group and the control group after treatment and before treatment was statistically significant(P<0.001).There was no statistically significant difference in CADI scores between the two groups after treatment(P=0.528).The difference in CADI scores between the observation group and the control group after treatment and before treatment in the same group was statistically significant(P<0.001).Conclusion The combination of fire-needing and 1540nm non-ablative fractional laser has a significant therapeutic effect on acne.