Objective To explore the clinical application of lymphocyte(L)to triglyceride(TG)ratio combined with 25-hydroxyvitamin D3[25(OH)D3]in diabetic nephropathy(DN).Methods 204 patients with DN were collected in the investigate in Shaoxing Hospital of Traditional Chinese Medicine from September 2020 to March 2022,and 101 genderand age-matched data of healthy people were collected for the investigate,and the results of blood lipid levels,some urinary microalbumin-to-creatinine(UACR),glomerular filtration rate(GFR),L,TG,and 25(OH)D3 and inflammatory indexes were statistically analyzed using Mann Whitney U-test between two groups and Kruskal-Wallis H-test between multiple groups.The observation group was divided into 4 DN subgroups based on UACR and GFR,including light risk group,medium risk group,heavy risk group and extremely heavy risk group.Binary logistic regression was used for multivariate analysis.The optimal index was determined by the receiver working curve(ROC)curve.Results Mann Whitney U-test showed that the levels of total GFR,25(OH)D3 and L/TG in patients with DN were significantly lower than those in healthy controls,while the levels of UACR and TG in DN patients were significantly higher than those in healthy controls.The difference was statistically significant(P<0.05).There was a correlation and consistency between L/TG and 25(OH)D3(r=0.16,P<0.001).In the observation group,Kruskal-Wallis H-test showed that the levels of L/TG and 25(OH)D3 in the light risk group,medium risk group,heavy risk group and extremely heavy risk group of DN gradually decreased,and the differences were statistically significant(P<0.05).Logistic regression analysis showed that L/TG and 25(OH)D3 were independent protective factors for late DN(P<0.05).ROC curve showed that there was no significant difference in the efficacy of the two alone,but the AUC of the combined detection of the two was 0.857,95%CI:(0.801～0.902),and the sensitivity and specificity were higher than those of the single detection.Conclusion L/TG and 25(OH)D3 are closely related to DN,and the combined detection of the two shows high accuracy,which is helpful for the early prevention of the disease.
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