Objective To investigate the application effectiveness of an Internet-based chronic disease management model in non-dialysis chronic kidney disease(CKD)patients.Methods A convenience sampling method was employed to select 220 non-dialysis CKD patients who received treatment at the nephrology outpatient department of a tertiary hospital in Jiaxing,Zhejiang Province,from August 2021 to March 2022.The patients were randomly assigned into the control group and the observation group,with 110 cases in each group.The control group received conventional outpatient guidance,while the observation group received management based on an Internet-based chronic disease management model.The self-management abilities and renal function indicators of both groups were compared before intervention,at 3 months after intervention,and at 6 months after intervention.Additionally,the unplanned hospitalization rates from the start of intervention to 6 months after intervention were compared.Results The study was completed with 106 cases in the control group and 109 cases in the observation group.At 3 months and 6 months after intervention,the observation group demonstrated significantly higher scores of self-management abilities and glomerular filtration rate(GFR)levels compared to the control group,with statistically significant differences(P<0.05).Furthermore,at 3 months and 6 months after intervention,the observation group had significantly lower SCr levels compared to the control group,with statistically significant differences(P<0.05).At 6 months after intervention,the unplanned hospitalization rate in the observation group was 9.17%,which was lower than the control group's rate of 25.47%,and the difference was statistically significant(P<0.05).Conclusion The application of an Internet-based chronic disease management model in non-dialysis CKD patients can enhance patients'self-management abilities,delay disease progression,and reduce unplanned hospitalization rates.