Objective To summarize and analyze the clinical characteristic and prognostic factors of COVID-19 caused by Omicron variants.Methods 349 cases of novel coronavirus pneumonia from December 2022 to January 2023 were analyzed retrospectively.According to the severity of the disease,the patients were divided into the non-critical group and the critical group.The data of general condition,underlying disease,clinical symptoms,laboratory examination,imaging findings,treatment and prognosis of patients were collected and statistically analyzed.Results The average age and the proportion of underlying diseases in the severe group were higher than those in the non-severe group,but the vaccination rate in the severe group was lower than that in the non-severe group(P＜0.05).The lymphocyte count and albumin level in the critical group were significantly lower than those in the non-critical group,while the C-reactive protein(CRP)level in the critical group was significantly higher than that in the non-critical group(P＜0.05).In terms of imaging,the lesions on chest CT images first admitted to the critical group were mainly manifested as solid shadow,ground glass shadow combined with solid shadow,while the lesions on chest CT images first admitted to the non-critical group were mainly manifested as ground glass shadow,ground glass shadow combined with solid shadow.Both groups showed the distribution characteristics of lesions with bilateral and multiple lung lobes involved and mainly in the outer bands of both lungs.There were 64 patients in the critical group,of which 23 were improved,38 died,and 3 were transferred to hospital.There were 285 patients in the non-critical group,among which 284 were improved,1 was transferred to hospital,and 0 died.There was statistical significance in prognosis between the two groups(P＜0.05).Multivariate Logistic regression analysis showed that the older the age(OR:1.076,95％CI:1.038～1.115),the higher the CRP(OR:1.022,95％CI:1.005～1.039)and the lower the albumin(OR:0.723,95％CI:0.530～0.986),the higher the risk of death of severe patients(P＜0.05).Conclusion Age,CRP level and albumin level are the high risk factors affecting the prognosis of patients with severe COVID-19.In the course of clinical treatment,if these high risk factors exist in patients with COVID-19,early active intervention is needed to reduce mortality and improve the prognosis of patients.
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