Objective To investigate the relationship between serum interleukin-18(IL-18)and daytime sleepiness(EDS)status and adverse mood in patients with obstructive sleep apnea(OSA)with anxiety and depression.Methods 96 patients diagnosed with OSA and accompanied by depression and anxiety in our hospital were selected as the case group,and 100 simple OSA patients with basic age and gender matching were selected as the control group.Detected and compared the serum IL-18,Epworth Sleepiness Scale(ESS)score,Pittsburgh Sleep Quality Index(PSQI)score,Sleep Apnea Index(AHI),Nighttime Minimum Blood Oxygen Saturation(SaO2),and general data between the two groups.Multiple stepwise regression analysis was used to analyze the correlation between serum IL-18,ESD status,Hamilton Depression Scale(HAMD)score,and Hamilton Anxiety Scale(HAMA)score.Results The lowest SaO2,ESS score,PPSQI score,and AHI value of the case group patients were compared with the control group,and the difference was statistically significant(P＜0.05).The combination rate of IL-18 and ESD in the case group was higher than that in the control group(P＜0.05).SaO2 was negatively correlated with HAMA and HAMD scores(P＜0.05),while ESS score,PPSQI score,IL-18 level,combined ESD,AHI were positively correlated with HAMA and HAMD scores(P＜0.05).Conclusion OSA patients with anxiety and depression have significantly increased IL-18 levels and a higher rate of ESD consolidation.Elevated IL-18 and ESD are related to the severity of anxiety and depression.
万方数据
维普
