Objective To investigate the effects of ulinastatin adjuvant therapy on white blood cells(WBC),neutrophil percentage(NEU),C-reactive protein(CRP)and procalcitonin(PCT)in patients with sepsis in intensive care unit(ICU).Methods Fifty-eight patients with sepsis admitted to ICU of the First Affiliated Hospital of Wenzhou Medical University from January 2022 to April 2023 were selected for retrospective study.According to different treatment methods,they were divided into the control group and the ulinastatin group,29 cases in each group.The control group received conventional treatment,and the ulinastatin group was treated with ulinastatin on the basis of conventional treatment.The levels of WBC,NEU,CRP and PCT were recorded and compared between the two groups before treatment and at different time points(1 day,3 days,7 days and 14 days)after treatment.Results After treatment for different days,WBC,CRP,PCT and NEU in the control group and ulinastatin group were significantly lower than before treatment,and after 3 days,7 days and 14 days,four biomarkers in the ulinastatin group were significantly decreased compared with the control group,with statistical significance(P＜0.05).Conclusion Ulinastatin as an adjunct has a good therapeutic effect on sepsis patients in ICU.Combined ulinastatin therapy can significantly reduce the inflammatory response of patients and improve the clinical therapeutic effect.
万方数据
维普
