摘要
目的 探讨乌司他丁辅助治疗对重症监护病房(ICU)脓毒症患者白细胞(WBC)、中性粒细胞百分比(NEU)、C-反应蛋白(CRP)和降钙素原(PCT)的影响.方法 回顾性分析2022年1月至2023年4月58例脓毒症患者的临床资料,根据治疗方法不同,分为对照组和观察组各29例.对照组予常规治疗,观察组在常规治疗的基础上,加用乌司他丁辅助治疗.记录并比较两组患者在治疗前和治疗后不同时间点(1d、3d、7d和14d)的WBC、NEU、CRP、PCT水平.结果 治疗后,两组患者WBC、CRP、PCT和NEU均较治疗前明显下降,且在治疗3d、7 d和14d后,观察组四种指标的下降幅度均高于对照组,差异有统计学意义(P＜0.05).结论 乌司他丁作为辅助用药对ICU脓毒症患者不同疗程的治疗效果较好,可降低患者的炎性反应,提高临床治疗效果.
Abstract
Objective To investigate the effects of ulinastatin adjuvant therapy on white blood cells(WBC),neutrophil percentage(NEU),C-reactive protein(CRP)and procalcitonin(PCT)in patients with sepsis in intensive care unit(ICU).Methods Fifty-eight patients with sepsis admitted to ICU of the First Affiliated Hospital of Wenzhou Medical University from January 2022 to April 2023 were selected for retrospective study.According to different treatment methods,they were divided into the control group and the ulinastatin group,29 cases in each group.The control group received conventional treatment,and the ulinastatin group was treated with ulinastatin on the basis of conventional treatment.The levels of WBC,NEU,CRP and PCT were recorded and compared between the two groups before treatment and at different time points(1 day,3 days,7 days and 14 days)after treatment.Results After treatment for different days,WBC,CRP,PCT and NEU in the control group and ulinastatin group were significantly lower than before treatment,and after 3 days,7 days and 14 days,four biomarkers in the ulinastatin group were significantly decreased compared with the control group,with statistical significance(P＜0.05).Conclusion Ulinastatin as an adjunct has a good therapeutic effect on sepsis patients in ICU.Combined ulinastatin therapy can significantly reduce the inflammatory response of patients and improve the clinical therapeutic effect.
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