Objective To analyze the acute impact of lithium enhanced therapy on renal function in refractory elderly depression patients.Methods 305 patients with refractory depressive disorder admitted to the Second People's Hospital of Lishui from January 2021 to December 2022 were selected for the study,all patients received individualized Lithium carbonate treatment,collected clinical data such as age,gender,body mass index(BMI),etc,observed the changes in renal function and lithium poisoning in elderly and non elderly patients during lithium enhancement therapy,analyzed and identified the influencing factors of renal function changes after lithium enhanced therapy.Results Compared baseline estimated glomerular filtration rate(eGFR)between elderly patients and non elderly patients before lithium enhanced therapy,the difference was statistically significant(P＜0.05).There were significant changes in eGFR during lithium enhanced therapy in both the elderly and the non elderly groups(P＜0.05).The univariate analysis results of the generalized estimation equation showed that elderly,female,combined use of nephrotoxic drugs,high Charlson comorbidities index(CCI)scores,and high serum lithium levels were associated with changes in renal function after lithium enhanced therapy(P＜0.05).The results of multivariate analysis showed that elderly,female,high CCI scores,and high serum lithium levels were independent influencing factors for renal function reduction after lithium enhanced therapy(P＜0.05).Conclusion Refractory depressive disorder patients with elderly,female,high CCI scores,and high serum lithium levels may have a higher risk of acute renal function damage during lithium augmentation therapy.It is recommended that clinical doctors closely monitor,strengthen medication monitoring,and provide early intervention to reduce the acute impact of lithium augmentation therapy on renal function.
万方数据
维普
